ND Biosciences

Publications on Biomarker Discovery
for Parkinson’s and Huntingtin’s Disease

  • Petricca L, Chiki N, Hanna-El-Daher L, Aeschbach L, Burai R, Stoops E, Fares MB, Lashuel HA. Comparative Analysis of Total Alpha-Synuclein (αSYN) Immunoassays Reveals That They Do Not Capture the Diversity of Modified αSYN Proteoforms. J Parkinsons Dis. 2022;12(5):1449-1462. doi: 10.3233/JPD-223285. PMID: 35527570.
  • Cariulo C, Verani M, Martufi P, Ingenito R, Finotto M, Deguire SM, Lavery DJ, Toledo-Sherman L, Lee R, Doherty EM, Vogt TF, Dominguez C, Lashuel HA, Petricca L, Caricasole A. Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13. Biochem Biophys Res Commun. 2020 Jan 15;521(3):549-554. doi: 10.1016/j.bbrc.2019.09.097. Epub 2019 Oct 31. PMID: 31677786.
  • Cariulo C, Martufi P, Verani M, Azzollini L, Bruni G, Weiss A, Deguire SM, Lashuel HA, Scaricamazza E, Sancesario GM, Schirinzi T, Mercuri NB, Sancesario G, Caricasole A, Petricca L. Phospho-S129 Alpha-Synuclein Is Present in Human Plasma but Not in Cerebrospinal Fluid as Determined by an Ultrasensitive Immunoassay. Front Neurosci. 2019 Aug 22;13:889. doi: 10.3389/fnins.2019.00889. PMID: 31507364; PMCID: PMC6714598.
  • Cariulo C, Azzollini L, Verani M, Martufi P, Chiki A, Deguire SM, Cherubini M, Gines S, Marsh LJ, Lavery D, Doherty E, Conforti P, Cattaneo E, Santimone J, Squitieri F, Lashuel HA, Petricca L, and Caricasole A. Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation, Proceedings of the National Academy of Sciences. 2017, 114(50): E10809-E10818.
  • Mollenhauer B, Batrla B, El-Agnaf O, Galasko DR, Lashuel HA, Merchant KM, Shaw LM, Selkoe DJ, Umek R, Vanderstichele H, Zetterberg H, Zhang J, Caspell-Garcia C, Coffey C, Hutten SJ, Frasier M, Taylor P for the Investigating Synuclein Consortium of the Michael J. Fox Foundation for Parkinson’s Research. A user’s guide for α-synuclein biomarker studies in biological fluids: Peri-analytical considerations. Journal of Movement Disorder. 2017, 32(8):1117-1130.
  • Verani M, Bustamante M, Martufi P, Daldin M, Cariulo C, Azzollini L, Fodale V, Puglisi F, Weiss A, Macdonald D, Petricca L, Caricasole A. Conformational modulation mediated by polyglutamine expansion in CAG repeat expansion disease- associated proteins. Biochem Biophys Res Commun. 2016 Sep 16;478(2):949-55. doi: 10.1016/j.bbrc.2016.08.057. Epub 2016 Aug 9. PMID: 27520369.
  • Schmid A, Fauvet B, Moniatte M, and Lashuel HA. Alpha-synuclein post-translational modifications as potential biomarkers for Parkinson’s disease and other synucleinopathies., Molecular and Cellular Proteomics. 2013, 12(12):3543-58.
  • Massai L, Petricca L, Magnoni L, Rovetini L, Haider S, Andre R, Tabrizi SJ, Süssmuth SD, Landwehrmeyer BG, Caricasole A, Pollio G, Bernocco S. Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells. BMC Biochem. 2013 Nov 25;14:34. doi: 10.1186/1471-2091-14-34. PMID:24274906; PMCID: PMC4221641.