ND Biosciences

Publications on Elucidating Mechanisms
Underlying Neurodegenerative Diseases

  • El Turk F, De Genst E, Guilliams T, Fauvet B, Hejjaoui M, Vendruscolo M, Lashuel HA, Dobson CM. “Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding”. Protein Science2018, (7):1262-1274.
  • Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA. Parkinson Disease Mutant E46K Enhances α-Synuclein Phosphorylation in Mammalian Cell Lines, in Yeast, and in VivoJournal of Biological Chemistry. 2015 Apr 10;290(15):9412-27.
  • Droste P, Frenzel A, Steinwand M, Pelat T, Thullier P, Hust M, Lashuel HA, Dübel S. Structural differences of Amyloid-b fibrils revealed by antibodies from phage display. BMC Biotechnology. 2015;15(1):57. doi: 10.1186/s12896-015-0146-8.
  • Fares MB, Ait-Bouziad N, Dikiy I, Mbefo MK, Jovičić A, Kiely A, Holton JL, Lee SJ, Gitler AD, Eliezer D, Lashuel HA. The novel Parkinson’s disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells. Human Molecular Genetics2014, 23(17):4491-509.
  • Jeong JS, Ansaloni A, Mezzenga R, Lashuel HA, and Dietler G. Novel mechanistic insight into the molecular basis of amyloid polymorphism and secondary nucleation during amyloid formation. Journal of Molecular Biology2013, 425(10):1765-81.
  • Wang Z and Lashuel HA. Discovery of a novel aggregation domain in the Huntingtin Protein: Implications for the mechanisms of Htt aggregation and toxicity. 2013, Angewandte Chem. Int. Ed. 2013 Jan 7;52(2):562-7.
  • Fauvet B., Mebfo MK, Fares MB, Desobry C, Michael S, Ardah MT, Tsika E, Coune P, Eliezer D, Moore DJ, Schneider B, Aebischer P., El-agnaf OM, Masliah E, and Lashuel HA. Alpha-synuclein in the central nervous system, in mammalian cells, and produced by E. coli exists predominantly as a disorderd monomer. Journal of Biological Chemistry2012, 287, 15345-15364
  • Jan A and Lashuel HA. Biophysical Approaches for Establishing the Links between Aβ aggregation and toxicity. Methods in Molecular Biology2012, 849, 227-43
  • Mbefo MK, Paleologou KE, Boucharaba A, Oueslati A, Olschewski D, Schell H, Fournier M, Zweckstetter M., Kahle PJ, Masliah E Hirling H, Lashuel HA. Phosphorylation of synucleins (α, β and g) by members of the Polo Like family of Kinases, PLKs 1-4. Journal of Biological Chemistry2010, 285(4):2807-22.
  • Oueslati A, Fournier M, and Lashuel HA. Role of post-translational modifications in modulating α-synuclein structure, aggregation and toxicity: implications for Parkinson’s disease pathogenesis and therapies. Progress in Brain Research2010;183C:115-145.
  • Jan A, Goekce Ol, Luthi-Carter R, and Lashuel HA. The ratio of monomeric/ aggregatedforms of Ab (40&42) is an important determinant of Ab aggregation and fibrillogenesis in Alzheimer’s diseases. Journal of Biological Chemistry2008, 283(42):28176-89.