Publications on Protein Engineering Technologies
Related to Alzheimer’s Disease
- Haj-Yahya M and Lashuel HA. Protein semisynthesis provides access to Tau disease-associated post-translational modifications (PTMs) and paves the way to deciphering the Tau PTM code in health and disease states. Journal of the American Chemical Society (JACS). 2018, I Apr 23. doi: 10.1021/jacs.8b02668.
- Ait-Bouziad N, Lv G, Mahul-Mellier AL, Xiao S, Zorludemir G, Eliezer D, Walz Tand Lashuel HA. Discovery and Characterization of Novel Stable Tau Oligomeric Complexes: Implications for the Role of Tau/Phospholipid Interactions in Regulating its Functions in Health and Disease. Nature Communications. 2017, 8, 1, 1678, 2017.
- Adamcik J, Sánchez-Ferrer A, Ait-Bouziad N, Reynolds NP, Lashuel HA, Mezzenga R. Microtubule-Binding R3 Fragment from Tau Self-Assembles into Giant Multistranded Amyloid Ribbons. Angewandte Chem. Int. Ed. 2016, 11;55(2):618-22.
- Jan A, Hartley DM and Lashuel HA. Preparation and characterization of toxic Aβ intermediates for structural and functional studies in Alzheimer’s disease research. Nature Protocols. 2010;5(6):1186-209.
- Lashuel HA, Hartley D, Petre B, Wall, Simon M, Walz T, Lansbury PT. Mixtures of wild-type and a pathogenic (E22G) form of ABeta40 in vitro accumulate protofibrils, including amyloid pores. Journal of Molecular Biology. 2003, 332, 795-808.
- Lashuel HA, Petre B, Wall, Simon M, Nowak RJ, Walz T, Lansbury PT. -Synuclein, Especially the Parkinson’s Disease-Associated Mutants, Form Pore-like Annular and Tubular Protofibrils. J. Mol. Biol. 2002. 322, 5, 1089-1102